Can erythrocytes behavior in microcirculation help the understanding the physiopathology and improve prevention and treatment for covid-19?

Low plasma estrogens, vitamin D deficiency, obesity, diabetes, cardiovascular diseases, thromboembolism, and impaired microcirculation are linked to the severity of covid-19. Studies have suggested that these comorbidities also related erythrocyte factors increased blood viscosity in such as aggregation deformability. Increased can lead a decrease oxygenation nutrition tissues. Therefore deformability may be involved covid-19 severity, leading tissue hypoxia drug concentration affected organs. If this relationship is demonstrated, erythrocytes used monitor treatments for improve microcirculatory fluidity severity. Lifestyle improvement estrogens supplementation some possible approaches prevention treatment.